1. Wrap your Adsense code with its own div class and css style the background.
This works well with 728 x 90 banner ads, especially if your website is wider and you want to center the Adsense code.You can add a color to the div background and add padding so that it separated the ad block from the rest of your content.Often the ads can make a website look very messy so separating them from the rest of your website will help to clean it up and people will see them better. You will also want to add the same background color to your Adsense code as you have with your div background.
2. 728 x 90 – Leader board
300 x 250 – Medium Rectangle
336 x 280 – Large Rectangle
160 x 600 – Skyscraper
Though it is no secret and this has being reported all over the internet this is actually quite a big issue, especially for those who have only just started with Adsense. Though there are quiet a few other ad block sizes available, those 4 work the best by far in my experience.
3. Lay your website out to allow for AdSense. Ads that get overlooked tend to be ones which alert the reader “these are tacky ads” or they completely miss them. The best ad placement for a forum is the banner ad at the top and bottom and also just below the first post. For a blog the best placements are just below the title using a 336 x 280 rectangle or in the sidebar above the page fold. Depending on your blog type you can also get good CTR by placing a 336 x 280 ad block or if wide enough 728 x 90 ad block at the end of your content. If you have a 3 column layout then the skyscraper blocks will work well. These work the best when you have them in the natural navigation areas, so usually on the left above the page fold. Here are the layouts I have found the best.4. Use Link units and also Google Custom Search. The link units are great and often look similar to navigation bars. The best placement is usually in areas close to where you would expect navigation buttons.
The best part is that you can create a custom search page, so the results look like they are within your own website. You make revenue when someone clicks a sponsored link in the search results.
5. Make sure you style the ads to fit in with your websites color and layout. Playing around with the color of your font on the ads is important and can often be overlooked or done terribly. The trick is to make the title a shade brighter than the titles on your website

